Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World Possibilities

The mismatch repair (MMR) system has a key role in supporting the DNA polymerase proofreading function and maintaining genome stability. Alterations MMR genes are driving events of tumorigenesis, tumor progression, resistance to therapy. These genetic scars may occur either hereditary or sporadic settings, with different frequencies across types. Appropriate characterization status is crucial task oncologic pathology because it allows for both tailored clinical management cancer patients surveillance individuals at risk. currently available testing methods have specific strengths weaknesses, their application types would require approach. This article highlights indications challenges assessment molecular pathologists, focusing on possible strategies overcome analytical pre-analytical issues.